Publications

Inhibitory probes for spatiotemporal analysis of Gα_s protein signaling. Zhao J, Luebbers A, Savaransky S, Lin TY, Cheng N, Wilcox A, Janicot R, Green E, Sharma A, Maziarz M, Varelas X, Irannejad R, Vilardaga JP, Garcia-Marcos M*. DOI: 10.1038/s41589-025-02138-1. Nat. Chem. Biol. 2026. PMID: 41634441

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist. #Liccardo F, #Morstein J, Lin TY, Pamel J, Shokat KM  and Irannejad R*. bioRxiv 2023, doi.org/10.1101/2023.11.22.568314  and PNAS 2024, September 27, 121 (40) e2404243121. PMID: 39331410

cAMP signaling: a remarkably regional affair. Bock A*, Irannejad R* and Scott JD*. Tends Biochem Sci, 2024 Apr, 49(4):305-317. Review doi: 10.1016/j.tibs.2024.01.004.

Anionic phospholipids determine G protein coupling selectivity at distinct subcellular membrane compartments.  Hernandez EH, Manglik A and Irannejad R*, bioRxiv, 2023 .doi: https://doi.org/10.1101/2023.08.31.555797

Cardiac Contraction and relaxation are regulated by distinct subcellular cAMP pools. #Lin T,#Mai QN, Zhang H, Wilson E, Chien H, Yee S, Giacomini KM, Olgin JE and Irannejad* R. bioRxiv 2023, doi.org/10.1101/2022.07.13.499965 and Nat. Chem. Biol. 2024 Jan;20(1):62-73. doi: 10.1038/s41589-023-01381-8. Epub 2023 Jul 20.PMID: 37474759

The Organic Cation Transporter 2 Regulates Dopamine D1 Receptor Signaling at the Golgi Apparatus. Puri NM, Romano GR, Lin T, Mai QN, Irannejad R*. bioRxiv. doi: https://doi.org/10.1101/2020.11.23.394445 and eLife 2022; 11:e75468

G-protein Regulated Endocytic Trafficking of Adenylyl Cyclase Type 9.  Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M. eLife  2020 Jun 9;9:e58039. doi: 10.7554/eLife.58039.

Emerging role of compartmentalized G protein-coupled receptor signaling in the cardiovascular filed.  Plouffe B, Thomsen ARB and  Irannejad R. ACS Pharmacol. Transl. Sci. 2020 Feb 24.

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. Yee S, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R,  Yu B, Giacomini KM. Plos Genet.  2019 Sep 25;15(9).

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Nash CA, Wei W, Irannejad R, Smrcka AV. eLife 2019 Aug 21;8.

Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles.
Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L. J Am Chem Soc. 2018.  Aug 22.

Functional selectivity of GPCR-directed drug action through location bias.
Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M and von Zastrow M. Nat. Chem. Biol. 2017. Jul 13; 13(7):799-806

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
Varandas KC, Irannejad R, von Zastrow M. Curr Biol. 2016 Dec 5;26(23):3129-3142

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.
Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. J Biol Chem. 2016 Jul 8;291(28):14510-25.

Effects of endocytosis on receptor-mediated signaling.
Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. Curr Opin Cell Biol. 2015 Aug;35:137-43.

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.
Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. Mol Biol Cell. 2015 Mar 15;26(6):1188-98.

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
Tsvetanova NG, Irannejad R, von Zastrow M. J Biol Chem. 2015 Mar 13;290(11):6689-96.

GPCR signaling along the endocytic pathway.
Irannejad R, von Zastrow M. Curr Opin Cell Biol. 2014 Apr;27:109-16.

Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
Irannejad R, Kotowski SJ, von Zastrow M. Methods Enzymol. 2014;535:403-18.

Conformational biosensors reveal GPCR signalling from endosomes.
Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Nature. 2013 Mar 28;495(7442):534-8. See also News and Views.

Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.
Irannejad R, Wedegaertner PB. J Biol Chem. 2010 Oct 15;285(42):32393-404.

Assembly and trafficking of heterotrimeric G proteins.
Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Biochemistry. 2007 Jul 3;46(26):7665-77.