{"id":52,"date":"2017-04-04T20:55:06","date_gmt":"2017-04-04T20:55:06","guid":{"rendered":"https:\/\/irannejadlab.ucsf.edu\/?page_id=52"},"modified":"2026-02-05T17:24:45","modified_gmt":"2026-02-05T17:24:45","slug":"publications","status":"publish","type":"page","link":"https:\/\/irannejadlab.ucsf.edu\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Inhibitory probes for spatiotemporal analysis of G\u03b1s<\/sub>\u00a0protein signaling<\/a>. Zhao J, Luebbers A, Savaransky S, Lin TY, Cheng N, Wilcox A, Janicot R, Green E, Sharma A, Maziarz M, Varelas X, Irannejad R, Vilardaga JP, Garcia-Marcos M*. DOI:\u00a0<\/span>10.1038\/s41589-025-02138-1. <\/span>Nat. Chem. Biol<\/strong>. 2026. PMID:\u00a0<\/span>41634441<\/span><\/h3>\n

Subcellular activation of \u03b2-adrenergic receptors using a spatially restricted antagonist. <\/a>#Liccardo F<\/strong>, #Morstein J<\/strong>, Lin TY, Pamel J, Shokat KM\u00a0 and Irannejad R<\/strong>*. bioRxiv <\/strong>2023, doi.org\/10.1101\/2023.11.22.568314\u00a0 and PNAS<\/strong> 2024, September 27, 121 (40) e2404243121. PMID: 39331410<\/h3>\n

cAMP signaling: a remarkably regional affair.<\/a> Bock A*, Irannejad R* and Scott JD*. Tends Biochem Sci<\/strong>, 2024 Apr, 49(4):305-317. Review doi: 10.1016\/j.tibs.2024.01.004.<\/span><\/h3>\n

Anionic phospholipids determine G protein coupling selectivity at distinct subcellular membrane compartments.\u00a0 <\/span><\/a>Hernandez EH<\/strong>, Manglik A and Irannejad R<\/strong>*, bioRxiv<\/strong>, 2023 .doi: https:\/\/doi.org\/10.1101\/2023.08.31.555797<\/h3>\n

Cardiac Contraction and relaxation are regulated by distinct subcellular cAMP pools.<\/a> #<\/span>Lin T<\/strong>,<\/span>#Mai QN<\/strong>, <\/span><\/span><\/span>Zhang H, Wilson E, Chien H, Yee S, Giacomini KM, Olgin JE and Irannejad<\/strong>* R. <\/span>bioRxiv <\/strong>2023, doi.org\/10.1101\/2022.07.13.499965 and <\/span>Nat. Chem. Biol<\/strong>. 2024 Jan;20(1):62-73. doi: 10.1038\/s41589-023-01381-8. Epub 2023 Jul 20.<\/span>PMID:\u00a037474759<\/span><\/span><\/h3>\n

The Organic Cation Transporter 2 Regulates Dopamine D1 Receptor Signaling at the Golgi Apparatus.<\/a> Puri NM<\/strong><\/span><\/span>, Romano GR<\/span><\/span>, Lin T, Mai QN<\/span><\/span>, Irannejad R<\/strong>*. bioRxiv<\/strong>. <\/span><\/span><\/span>doi:<\/span> https:\/\/doi.org\/10.1101\/2020.11.23.394445 and <\/span>eLife <\/strong>2022; 11:e75468<\/span><\/h3>\n

G-protein Regulated Endocytic Trafficking of Adenylyl Cyclase Type 9.<\/a>\u00a0 Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M. eLife <\/strong>\u00a02020 Jun 9;9:e58039. doi: 10.7554\/eLife.58039.<\/h3>\n

Emerging role of compartmentalized G protein-coupled receptor signaling in the cardiovascular filed.<\/a>\u00a0\u00a0Plouffe B, Thomsen ARB and\u00a0\u00a0Irannejad R.\u00a0ACS Pharmacol. Transl. Sci.<\/span><\/strong>\u00a02020\u00a0Feb\u00a024.<\/h3>\n

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.<\/a>\u00a0Yee S<\/span><\/span>,\u00a0Stecula A<\/span><\/span>,\u00a0Chien HC<\/span><\/span>, Zou L<\/span><\/span>,\u00a0Feofanova EV<\/span><\/span>,\u00a0van Borselen M<\/span><\/span>,\u00a0Cheung KWK<\/span><\/span>,\u00a0Yousri NA<\/span><\/span>,\u00a0Suhre K<\/span><\/span>,\u00a0Kinchen JM<\/span><\/span>,\u00a0Boerwinkle E<\/span><\/span>,\u00a0Irannejad R<\/span><\/span>,\u00a0\u00a0Yu B<\/span><\/span>,\u00a0Giacomini KM. Plos\u00a0Genet.\u00a0<\/strong>\u00a02019\u00a0Sep 25;15(9).<\/span><\/span><\/h3>\n

Golgi localized \u03b21-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLC\u03b5 to regulate cardiac hypertrophy.<\/a> Nash CA, Wei W, Irannejad R, Smrcka AV. eLife<\/span><\/strong>\u00a02019 Aug 21;8.<\/h3>\n

Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles.<\/a>
\nFu C, Kobayashi T, Wang N, Hoppmann C, Yang B,\u00a0Irannejad R, Wang L.\u00a0J Am Chem Soc<\/strong><\/span>. 2018.\u00a0\u00a0Aug 22.<\/h3>\n

Functional selectivity of GPCR-directed drug action through location bias.<\/a>
\nIrannejad R<\/strong>, Pessino V,\u00a0Mika D,\u00a0Huang B, Wedegaertner PB, Conti M and von Zastrow M. Nat. Chem. Biol<\/strong>. 2017. Jul 13; 13(7):799-806<\/h3>\n

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
\n<\/a>Varandas KC, Irannejad R, von Zastrow M.\u00a0Curr Biol<\/span><\/strong>. 2016 Dec 5;26(23):3129-3142<\/h3>\n

The \u03b1-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the \u03b22-Adrenergic Receptor.
\n<\/a>Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL.\u00a0J Biol Chem<\/span><\/strong>. 2016 Jul 8;291(28):14510-25.<\/h3>\n

Effects of endocytosis on receptor-mediated signaling.
\n<\/a>Irannejad R<\/strong>, Tsvetanova NG, Lobingier BT, von Zastrow M.\u00a0Curr Opin Cell Biol<\/span><\/strong>. 2015 Aug;35:137-43.<\/h3>\n

G protein \u03b2\u03b3 subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.
\n<\/a>Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV.\u00a0Mol Biol Cell<\/span><\/strong>. 2015 Mar 15;26(6):1188-98.<\/h3>\n

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
\n<\/a>Tsvetanova NG, Irannejad R, von Zastrow M.\u00a0J Biol Chem<\/span><\/strong>. 2015 Mar 13;290(11):6689-96.<\/h3>\n

GPCR signaling along the endocytic pathway.
\n<\/a>Irannejad R<\/strong>, von Zastrow M.\u00a0Curr Opin Cell Biol<\/span><\/strong>. 2014 Apr;27:109-16.<\/h3>\n

Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
\n<\/a>Irannejad R, Kotowski SJ, von Zastrow M.\u00a0Methods Enzymol<\/span><\/strong>. 2014;535:403-18.<\/h3>\n

Conformational biosensors reveal GPCR signalling from endosomes.
\n<\/a>Irannejad R<\/strong>, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M.\u00a0Nature<\/span><\/strong>. 2013 Mar 28;495(7442):534-8. See also News and Views<\/a>.<\/h3>\n

Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.
\n<\/a>Irannejad R<\/strong>, Wedegaertner PB.\u00a0J Biol Chem<\/span><\/strong>. 2010 Oct 15;285(42):32393-404.<\/h3>\n

Assembly and trafficking of heterotrimeric G proteins.
\n<\/a>Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB.\u00a0Biochemistry<\/span><\/strong>. 2007 Jul 3;46(26):7665-77.<\/h3>\n","protected":false},"excerpt":{"rendered":"

Inhibitory probes for spatiotemporal analysis of G\u03b1s\u00a0protein signaling. Zhao J, Luebbers A, Savaransky S, Lin TY, Cheng N, Wilcox A, Janicot R, Green E, Sharma A, Maziarz M, Varelas X, Irannejad R, Vilardaga JP, Garcia-Marcos M*. DOI:\u00a010.1038\/s41589-025-02138-1. Nat. Chem. Biol. 2026. PMID:\u00a041634441 Subcellular activation of \u03b2-adrenergic receptors using a spatially restricted antagonist. #Liccardo F, #Morstein … <\/p>\n

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