Publications

Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles.
Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L. J Am Chem Soc. 2018.  Aug 22.

Functional selectivity of GPCR-directed drug action through location bias.
Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M and von Zastrow M. Nat. Chem. Biol. 2017. Jul 13; 13(7):799-806

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.
Varandas KC, Irannejad R, von Zastrow M. Curr Biol. 2016 Dec 5;26(23):3129-3142

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.
Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. J Biol Chem. 2016 Jul 8;291(28):14510-25.

Effects of endocytosis on receptor-mediated signaling.
Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. Curr Opin Cell Biol. 2015 Aug;35:137-43.

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.
Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. Mol Biol Cell. 2015 Mar 15;26(6):1188-98.

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
Tsvetanova NG, Irannejad R, von Zastrow M. J Biol Chem. 2015 Mar 13;290(11):6689-96.

GPCR signaling along the endocytic pathway.
Irannejad R, von Zastrow M. Curr Opin Cell Biol. 2014 Apr;27:109-16.

Investigating signaling consequences of GPCR trafficking in the endocytic pathway.
Irannejad R, Kotowski SJ, von Zastrow M. Methods Enzymol. 2014;535:403-18.

Conformational biosensors reveal GPCR signalling from endosomes.
Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Nature. 2013 Mar 28;495(7442):534-8. See also News and Views.

Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.
Irannejad R, Wedegaertner PB. J Biol Chem. 2010 Oct 15;285(42):32393-404.

Assembly and trafficking of heterotrimeric G proteins.
Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Biochemistry. 2007 Jul 3;46(26):7665-77.